War. War never changes. No matter how far humanity advances, the means and motives of war stay the same. After being awoken from spending countless years in cryostasis, Makoto Naegi learns the truth about the outside world: it's all gone to nuclear hell. Now living as a resident in Hope's Peak's vault, Makoto and the dwellers must face something far worse than the Wasteland...
After the success of the Heart-Throbbing School Trip, a reformed Nagito Komaeda accompanies Makoto Naegi to a meeting at the Future Foundation base to decide the fate of the former Ultimate Despairs. He is reunited with several people, including his former lover Seiko Kimura. But after narrowly evading one Killing Game, Nagito soon finds himself about to participate in another one.
Junko has her plan set in motion. Everything is set in place. It seems like everything might end up becoming really tragic for Hope's Peak Academy and no one even knows it. However, what if one person did know and tried to stop her? This is the story of a young person by the name of Riki Aiuchi, a Reserve Course student that would end up making more happen than he anticipated...
After being suspended from Hope's Peak Academy following the bombing of the school gymnasium, Nagito Komaeda crosses paths with an unintended victim of his perceived hopeful actions: Seiko Kimura, the Ultimate Pharmacist.
Yoshiro Nishimura, the Ultimate Marine Biologist, decided to go and meet up with the shy girl in your class, Seiko Kimura. He wanted to make sure she was doing alright. Across this story, he'll try to connect with her on a deeper level, and she begins to wonder if she is developing feelings for him or not. But a dangerous crime subplot is lurking just around the corner...