Post "Galactus Seed", Pre #622 "Fear, Itself". Thor is no fool. It is impossible to miss the scorn, abuse, and pain his brother faces by just trying to get through the day in an Asgard that holds him responsible for a dead man's crimes. But sometimes, all he knows of how much it weighs on Loki are the cracks that form in his brother's smiling mask, and the dead look in his eyes.
In the middle of the night, Loki is standing outside Thor's door. He's had another nightmare and needs to talk about it. One-shot. No pairings.
It's not that she doesn't look forward to their rendezvous. On the contrary, she anticipates them too eagerly for her liking.