The Ghostbusters head to rural Connecticut and Lydia Deetz is forced to defend her ghost friends, whom are thought to be a threat. Beetlejuice is unknowingly summoned and it's up to Lydia and the Maitlands to send the vengeful ghost back to the grave…again. Can Lydia find a way to work together with the strong-willed scientists or will Beetlejuice outsmart even the Ghostbusters?
After six and a half years Lydia's father finally calls on the Ghostbusters to investigate his house for signs of haunting. Now the problematic questions are will the Ghostbusters bust Beetlejuice, or will he juice them before they have a chance? Most importantly, how will Lydia's parents react to finding out about her ghoulish best friend who's been causing them trouble for years?