A teen with a troublesome injury is brought to the doctors at Seattle Grace. Turns out she's the latest victim in a case handled by a certain Boston detective/medical examiner team.
When Constance Isles dies, she leaves her only daughter, Dr. Maura Isles, with a picture of her birth parents so she can if she wants try and find them. Will she do it? Will she be ready to do what she has always wanted to? Or will she stay within the boundaries she has set for her life and simply ignore one of her deepest desires, the desire to have a family, brothers and sisters?