((post-Blue Sea ending, major spoilers)) It's never been quite the same since she vanished. Not for any of her familiars, and especially not Fukami. (implied fukawadas)
Yoshiya "Joshua" Kiryu didn't have many weaknesses, but there was one particularly persistent one that just kept coming back to bite him... ((spoilers ahoy))
Eight hundred years was a rather long period for a continuity timeskip- even so, two people seemed to stay the same.