Timmy Turner's arch nemesis are teaming up with the fearsome five to kidnap all of Timmy's friends and its up to Darkwing Duck the Justice Ducks and Trixie and Veronica to stop the villains from conquering Dimsdale and Saint Carnard.

Madam Medusa and Mr Snoops and then Mcleach team up with Ammonia Pine and Steelbeak capture the Rescuers and the children to destroy and conquer the world. And then Darkwing gets help from the swamp critters and as well as the justice ducks to team up and take those villains down.