When an organization creates robots that can traverse universes, Black Jack feels it is wrong to use the new technology as they are currently using it. When the organization that controls all the traversing machines reveals its true intentions, can Black Jack and his new acquaintances stop the organization before it controls literally everything in existence?

Few know that Kintobor is still in Eggman, so when he is frozen instead of Eggman, nobody notices, but now half of all the evil in Mobius is loose without a buffer or filter in the middle of Arendelle. To win, many people make a sacrifice; but sometimes, it never required it in the first place.

After the events of Black Jack 21, the Hydra Organization is left in shambles. Just when Black Jack thought his life was back to 'normal', A new Phoenix rises out of the ashes, and he's a demon. A demon in an angel's robe. Can Black Jack stop the ace and defeat the new virus specifically designed to outmatch him?