(Inspired by 1999's Blue Gender) Scott Gavin awakens years in the future to a world ravaged by a mysterious virus and hostile aliens, learning later that he may be carrying potential cure within himself. With a group of brave soldiers, including the deeply troubled Johansson, Scott embarks on a personal journey to reach Sky Haven, where he hopes to reunite with his missing brother.

Peter Parker and Gwen Stacy find their lives reaching a crossroads, with Gwen unaware that Peter is also Spider-Man, the man she blames of her father's death. Meanwhile, the Green Goblin resurfaces to wage war against the crime lords of New York, putting him on a collision course with Spider-Man that could lead to the most personal battle either of them have ever faced.