After giving in to silly pressure, Kagome finally decides to apply to Japan's infamous Shikon University. Soul Games held during the summer for finals determines who will become sole proprietor of the Jewel of Four Souls & Kikyo feels she shouldn't have to compete for what is hers. Jealous of Kagome & her powers, Kikyo will stop at nothing to have the jewel for her taking.

Sakura & Ayame Tsuyotomi are legendary cross-species demons who suffered rough childhoods of nonacceptance because of their parents bearing two children of cat/dog mix. Being a victim of Naraku's hatred, the sisters were raised by Kaede and left the Feudal Era when they grew older. Upon returning, they meet Inuyasha & his friends & embark on a wild journey to defeat Naraku.