After fusing his mind to Squeaky's less than three hours ago, Dr. Two Brains is on the run with nowhere to go and no place to hide. Luckily for him, he comes across a couple of friendly strangers with an unusual desire to assist him.

Now that Dr. Two Brains is trying to adjust to life as a wanted criminal, he attempts to befriend some of his fellow villains at his first-ever villain's convention meeting.

Dr. Two Brains goes on a mysterious trip to a place he had almost forgotten.