When best bros Cole MacGrath and Zeke Dunbar enter through a vortex that leads them out of Empire City, they finds themselves in another, known as Heckseville. There, they meet an unlikely pair named Kat and Dusty. As the four work together, they fight monster known as Nevi and save the city and gaining the trust of the people.

Pokémon trainers Ash Ketchum, May, Serena, Clemont and Bonnie find themselves in another world, after being attacked by a stranger in black. In order to get home and locate his friends, Ash Ketchum teams up with a boy named Sora, a duck Donald and a dog Goofy to stop the darkness from spreading throughout the worlds.

Abandoning his role as a superhero, Cole MacGrath and Zeke Dunbar leave Empire City and enter the town called Radiant Garden. There, Cole meets a woman named Aqua, aiding her in her quest to find Terra and Ventus, also developing a close bond with her.