A Citadel Research expedition in pursuit of Protean Relics is way laid by sabotage and conspiracy. Stranded on a desolate and inhospitable planet can the crew escape with the help of the locals or will they fall prey to the wastes like so many before.

When Commander Shepard receives a call for aid from the Alliance, his Mission against the Collectors is put on hold as he rushes to stop and inter-galactic war. Little does he know that a meeting with an unknown alien is only the beginning of a far stranger adventure, where the fates of entire Universes are put at risk. ME:2