Tanjiro Kamado was attacked by Muzan on his way home and turned into a demon. He manages to regain his humanity, but is soon decapitated by Water Hashira, Giyu Tomioka. However. Tanjiro regenerates for unlike every other demon, he was resistant to sunlight. After running away from home, Tanjiro must adapt to life as a demon while avoiding both Muzan and the Demon Slayer Corps.

Remnant is a cruel world. The creatures of Grimm terrorize its citizens, the demons come along to make things worse. But the Huntsmen of the four main kingdoms and the Demon Slayers of the fifth kingdom, Japan, work together to vanquish their enemies. Centuries later, a Huntress in training and a new Demon Slayer, along with their comrades, must bring peace to Remnant once again.