Somewhere within the far reaches of space, a lone drifter and his robotic companion find themselves escorting an unlikely passenger. Join Hubble as he and Gizmo attempt to escort Frankie Stein back home to her ghoul friends from Monster High in a galactic tale like no other.

After a quarrel with the Green Goblin over a mysterious talisman goes haywire, Young Peter Parker better known as Spider-Man ends up in a new place called Monster High and soon befriends Frankie Stein and most of the students at the school. But when his enemies come searching for him, Spider-Man must save the very soul of Monster High as well as take responsibility to a new level.