One of Spiderman's original enemies has been cured at long last. But celebrations are abruptly cut short when an accident at Oscorp turns demolition expert Morris Bench into the dangerous Hydro Man! Now the Spider Duo and their allies must stop Hydro Man's obsessive crusade of vengeance against the Kingpin, or else risk him drowning all of New York!

In the midst of the Spider duo's fight against Venom, a more terrifying foe enters the fray, Carnage! The malevolent monster has kidnapped Dr. Kafka, forcing Eddie to make a choice between revenge and redemption. It's a showdown of the symbiotes, one anti-hero, one psychopathic, and only one will walk away in the end.

In the aftermath of the battle with the Dark Master, Spyro, Cynder, and Sparx instantly find themselves transported across the stars to the world of the Precursors. Forging a team-up with Jak and Daxter, they set out to eliminate the metalhead threat, save Haven City, and find a way home. Takes place during Jak 2.