Since the dawn of man, humanity was threatened by the impending doom that is the Grimm. However, society has forgotten that there are other threats that the Grimm cannot hope to be. Especially if it threatens the human condition. In the wake of a deadly disease, four huntsmen in training must work together to fight their way to Vytal for the promise of extraction and survival.

Homura's battle victory that took place between her and the three Demons in the desert caused her unfortunate demise, but for some reason, her body never disappeared. Centuries later, a Ghost finds her remains and brings her back to the living, making her a Guardian. Now Homura faces a new threat that will not only threaten the Human race, but their neighboring planets as well.