Five years after Avengers, in 2017, Loki had finally completed the slave training (which was supposed to take 3 years) and is now thr into slavery on Midgard. Loki has a 4 year old child and his pregnant. Civil war didn't happen and Hulk is still on Earth, eventhough Ultron happen and the compound exist.
What is Sylvie's nexus event exactly? Well this is a theory. One Shot including the whole royal family.
Wanda is judged for her crimes in Westview by a coven of witches and is supported by Doctor Strange. Loosely inspired by the trailler of Doctor Strange 2, but really far from what will happen. Loki might have a small role later on, maybe. Spoilers from Endgame, Wandavision and Loki.