Caim had been certain that when he and the Red Dragon agreed to escort Seere to the Queen Beast, it would end in their shared demise. Yet once again, the unhinged prince has found himself avoiding an all but certain death, culminating in him being marooned in an alien land with even more alien inhabitants...

Upon escaping from Raccoon City with Claire and Sherry, Leon opts to continue his life as a police officer in New York. However, nothing good is meant to last, for he is soon thrown into another nightmare revolving around an ancient evil. Now, the Raccoon City survivor must work together with Aya Brea if they are to stand any chance against Mitochondria Eve. AyaxLeon.