Dante dies in his fight with Vergil, goes to Hell, and finds Dante Alighieri there. He finds out Alighieri is on a quest to escape and find Beatrice, and wants in. They now must go through all Nine Circles, all the while fighting off legions of hellspawn. Will they succeed, or will they be doomed to forever suffer?

Kratos is sent forward in time, looking for weapons to kill Zeus. He hears of a place known as Devil May Cry, that houses weapons of great power. But when the owner refuses to give up his arms, all hell breaks loose.