During a power outage, a few subjects escape their cages in the facility. The facility is put on lockdown leaving Rosalind to keep one subject, Elizabeth, safe until the creatures can be contained. Avoiding the creature will be hard enough but Rosalind was never meant to be a babysitter and it doesn't take long for her to realize that no one is coming to help her.

Rosalind Lutece wakes one day to find Elizabeth has been left on her doorstep. After speaking with Comstock, she agrees to watch over the child for a week. But that week turns into eternity when Comstock refuses to take the child back. With no other options, Rosalind and Robert raise Elizabeth themselves.