Dr. Nefarious Tropy has made a hole through the multiverse, as well as time and space, enabling him to multiple kidnappings, time tampering, and ilegal businesses. It's up to the heroes to stop the powerful master of time before the damage becomes permanent.

The evil Dr. Neo Cortex has teamed up with some of the most evil villians to take over the Multiverse. Now, it is up to the crazy marsupial, Crash Bandicoot, the mighty dragon, Spyro, the gorgeous Lara Croft, speedy Sonic, slacker Gex, the super fighting robot, Mega Man and the rest of heroes to save the Multiverse.