The Pound Puppies are trying to get two puppies adopted by Sue Patterson in Downtown City. So, they need Blythe and Zoe's help to pull it off.

Blythe takes the pets to the park to spend time with them, but Youngmee, and eventually everyone else, discovers that she can talk to pets.

Blythe and the pets have always had a strong relationship. However, when the Biskits kidnap the pets, Blythe has to make the ultimate sacrifice and reveal her ability to talk to pets in order to save them.

Blythe and her friends spend a day at the carnival. However, the Biskits come to challenge them. IN the sub plot, the pets meet a tree frog named Ted, who is very clumsy.

SpongeBob and friends go on a vacation on Titanic 2. Plankton tries to steal the formula, but there is a bigger threat onboard with ulterior motives.

Sunil accidentally turns Russell into a golden hedgehog, so he, Blythe, Vinnie, and the golden Russell go to Ponyville to get help from Twilight.

Blythe wins a contest to take part in Milan Fashion Week in Italy, and she brings her friends and family with her. But, the competition takes its toll on Blythe

The plot here is where Blythe, Mrs. Twombly, and the pets from Littlest Pet Shop and Spike and the Mane 6 from My Little Pony all get sucked into a joint comic book universe. In order to get back home , they need to stop the Mane-iac and the Biskit twins from using three silver keys that can help them rule the world.