Sherrelyn Holmes, the 'Holmes Girl', was taken from the Holmes family by Jim Moriarty. He intended to kill her, but her intelligence changed his rather fixed decision. He took her in as his apprentice, and together they cause trouble and they rule the London Underworld. But all that changes when she plays the great game.

Sherry Holmes, idolized her aunt when she was younger. But one can only wish to hear how wonderful Sherry was at least a dozen times, without getting sick of it! She used to love the idea of being like her, but now, all she wanted was for her father to shut up about his dead sister. Can her family stop putting Sherry on the shelf, or will she only be known as The Last Holmes Girl?

Crystal is a normal girl...except that she has the ability to move anything with her mind. She attracts the attention of S.H.I.E.L.D. and the God of Mischief, Loki.