For years, all Glen and Glenda had was each other. Having been born twice, with serial killers as parents and unusual ways of growing and thinking, there wasn't always room for friendship in their lives. Years later, they're living their dream lives while trying to uncover mysteries about themselves and their past, all while a girl they once knew seeks similar answers.

On New Year's Eve of 1938, the parents of the Lowell siblings are murdered, leaving them to cope in ways that lead to trouble. Jerry starts selling and using drugs, Clara stays out with boys late into the night, while Alice starts slipping into her own dream world called Wonderland, which might turn to be more than just another childish fantasy.