Skye and the team try to move on from Ward's betrayal, but with Fitz still in a coma, Coulson trying to rebuild shield and Skye's deteriorating mental state, it has become difficult to go back to normal. Meanwhile shield is having trouble 'breaking' Ward.

When Daisy is young, her village is burned to the ground by the ruthless Daniel Whitehall. 16 years later, she has no memories of her past and only a necklace found with her when she was young. Using the necklace she finds agents Grant and Fitz who are on a mission to find her for her father. Together hey travel to San Juan to help her reunite with her father and fulfil her destiny