Cold Noxian mercenary Talon had always been unmatched-his opponents always unworthy. But when his blades clash with Akali of the Kinkou Order, he discovers something he'd never known before-a worthy opponent and, much to his surprise, a friend. As a forbidden bond forms, she will help him with the strange disappearance of General DuCouteau and the growing anarchy of Noxus.

Delsin, Eugene, and Abigail are called to track down two mysterious and powerful Bio-terrorist thieves and make several unlikely allies, including a hotheaded hydrokinetic Conduit. Delsin encounters several new powers along the journey, while Fetch battles an emotional conflict. Eugene is haunted by the memory of a blue-eyed Conduit-a person who may be just who they're looking for.