After getting kicked to the curb by Dr. Samuel Hayden, the Slayer finds himself drifting inside an endless void. Our silent warrior soon enters an apocalyptic world where the living dead are walking. While making friends and foes along the way, the Slayer will have to fight once more. (Rated M for extreme violence, grim dark themes, sexual content, and profanity.)

Finally, after defeating Olivia Pierce as the Spider Mastermind, the Slayer returns to Mars, only to have Dr. Samuel Hayden confiscate the Crucible for "better use" in his research. To keep our silent hero from intruding with his future layouts, Hayden teleports him to an undisclosed location, stating that they will meet again. In this new world, the Slayer has to fight once more.