Firefighter and paramedic Claire Redfield is just trying to get through her shifts on the ambulance in September of 1998. When a nightmarish pandemic hits her city, her and the other emergency personnel must make a stand if they want to survive. It certainly doesn't hurt that the cute rookie who pulled her over previously still hasn't lost his charm. Men are weird sometimes.

Two months have passed since Leon Scott Kennedy failed to remove the Las Plagas from both himself and Ashley. As a result, Saddler has successfully gained two more followers that remain with him in Spain as he expands his control. Parts of Spain are starting to fall dark, and in desperation, the U.S. Government Agency is looking to take some risks before this becomes world news...