Dean is still a Demon. Deadpool is functionally crazy. And Charlie is finally back from Oz, and brought a couple new friends. Mainly Dorothy and Turple the Tiny Flying Monkey. After the ordeal with Vetis, all Dean wants is some peace and quiet, and maybe some time to figure out things with Wade. But Dean's never been good at getting what he wants.

Dean is a Demon. Deadpool is crazy. Both have a knack for not dying and dealing out justice with a blade. After a chance encounter leaves Deadpool's Team-Up Senses tingling, Dean Winchester and the infamous Merc with a Mouth go hunting for Deadpool's nemesis, Vetis. Well, sort of. When they are not being sidetracked by biblical figures, younger brothers, and Dean's demonic rage.