The Separatist Invasion of Kamino made one thing clear to the Kaminoans, that their security and autonomy was in jeopardy. The location of the original Fett samples were leaked from the top brass of the Republic, which allowed them to figure out the Clone Wars was staged. In response, the Kaminoans made a secret clone military that would challenge the future Galactic Empire.

After the creation of the Galactic Empire, the 501st was sent to eliminate an uprising on Kamino, involving several Kaminoan scientists. Officially, the 501st Legion had suppressed, destroyed what was left their rebellion, and captured Tipoca City. However, the Rebel Clones would eventually, a decade after, restore a Republic they once fought for. For this.. was a Clone Rebellion.